Musiksaal is internationally renowned for its excellent acoustics and is the home base of the Sinfonieorchester Basel.

The centerpiece of the Stadtcasino Basel is undoubtedly the Concert Hall, dating back to 1876. Its acoustics are among the best in the world. Besides its size, the hall's rich furnishings play a crucial role in this. Many of the interior design elements, chosen by the architect Johann Jakob Stehlin, a representative of Historicism, are reminiscent of Baroque concert halls. Stucco work, crystal chandeliers, busts, and portraits of famous composers create a truly unique ambiance while simultaneously ensuring optimal sound dispersion.

The founding members first met, in hired premises on Reinacherhof, in 1808; eventually the society required its own building, and from 1820 the architect Melchior Berri worked on plans. The Stadtcasino-Gesellschaft was officially established in 1824, and the original building at Steinenberg was completed in 1826.

Notable events held in the original building include the First Zionist Congress in 1897. Up until the establishment of the State of Israel in 1948, the Congress was held a total of ten times in the Steinenberg premises, more than in any other city or venue in the world.

In the late 1930s, because of financial difficulty, the original building was sold, and a new building was erected.

From 2000 there was a project to build a new Stadtcasino. Although an international competition was held for architects, and a winning project by Zaha Hadid was announced, the voters of the canton of Basel-Stadt refused permission in 2007 to proceed with the new building. It was proposed to make structural alterations and extensions to the existing building. The modifications, based on a study by architects Herzog & de Meuron, were carried out from 2016, and in 2020 the Stadtcasino Basel was officially reopened.

Depending on the stage size, the concert hall offers between 1,191 and 1,397 seats, 468 of which are located in the balcony.