The St. James Theatre is a Broadway theatre located at 246 West 44th Street in midtown Manhattan. With 1,710 seats over three levels, it is one of the largest Broadway theatres. The St. James Theatre, named after the famed St James's Theatre in London, is owned and operated by Jordan Roth, President, and owner of Jujamcyn Theaters. Kander and Ebb's musical adaptation of the film New York, New York is scheduled to open at the theater in April 2023. A brand-new musical bringing Broadway legends back together, New York, New York is a glittering love letter to the greatest city in the world.

Abraham L. Erlanger, theatrical producer and a founding member of the Theatrical Syndicate, constructed the St. James on the site of the original Sardi's restaurant. Designed by architects Warren and Wetmore (one of two firms that designed Grand Central Terminal), the theatre's simple brick facade is dominated by a large cast iron loggia, masking the fire escapes from the auditorium over the expansive street front. The gilded, landmarked auditorium is ornate, with two balconies. It opened in 1927 as The Erlanger Theatre. Upon Erlanger's death in 1930, the Astor family, who owned the land on which the theatre stood assumed control of the venue and renamed it the St. James Theatre.

The theatre was taken over by the Shuberts in 1941. They were forced to sell it to William L. McKnight in 1957 following the loss of an antitrust case. McKnight renovated the St. James and reopened it in 1958. In 1970, McKnight then transferred the theatre to his daughter Virginia and her husband James H. Binger, who had formed Jujamcyn Theaters. After Binger's death in 2004, producer and president of Jujamcyn, Rocco Landesman, announced his plans to buy the company. Landesman purchased the group in 2005, and in 2009 he sold half his stake to up-and-coming theatrical producer, Jordan Roth. Shortly after, Landesman was asked to head the NEA and Roth and assumed control of the group. The theatre has been home to a number of long-running and Tony Award-winning musicals in its ninety-one-year history, including original productions of Oklahoma!, The King and I, Hello, Dolly!, The Who's Tommy and The Producers. Located on 44th Street in the Theater District, the St. James neighbors a handful of large musical houses including the Majestic, Broadhurst, Shubert, and the Hayes Theater.

In 2017, the St. James completed a renovation which extended its stage by ten feet into the alley between the Hayes Theater and the St. James. The stage expansion was to accommodate the Broadway run of the Disney musical Frozen.

On June 7, 2021, Bruce Springsteen announced that he would give a limited run of 31 performances of his Springsteen on Broadway shows at the theatre beginning on June 26, 2021 with additional performances through September 4, 2021. His original run of his Broadway performances was held from 2017-18 at the Walter Kerr Theatre.