Palau de les Arts Reina Sofía (anglicised as "Queen Sofía Palace of the Arts") is an opera house, performing arts centre, and urban landmark designed by Santiago Calatrava to anchor the northwest end of the City of Arts and Sciences in Valencia, Spain. It opened on 8 October 2005; its first opera staging was of Beethoven's Fidelio on 25 October 2006. Tenor and conductor Plácido Domingo has maintained a special relationship with the Palau since its founding and has established a young singers training program there.

From its inception in 2005 until early 2015, administration of the company was under the General Directorship of Helga Schmidt, formerly of London's Royal Opera House from 1973 to 1981. Schmidt attracted some major artists to be involved with the Palau. Among them is Zubin Mehta, who leads an annual music and opera festival, the Festival del Mediterráneo, which began in 2007; the late Lorin Maazel, who became music director of the company before his death; and Plácido Domingo, who brought his Operalia competition to the Palau in October 2007, and performs there regularly (Cyrano de Bergerac in 2007, Iphigénie en Tauride in 2008, Die Walküre in 2009, etc.). He has appeared with the company every season since its creation.

The resident orchestra at the Queen Sofía Palace of the Arts is the Valencian Community Orchestra. The theatre's first season was dated, 2006–2007. During the first and second seasons the theatre staged seven or eight operas per season, as well as an operetta, a zarzuela, and vocal recitals. During the 2008–2009 season theatre staged seven operas and one zarzuela, in performances that mainly conducted by Lorin Maazel. Soloists included Plácido Domingo, Christopher Ventris, Vittorio Grigolo, Maria Guleghina, and Cristina Gallardo-Domâs. The 2008-2009 Festival del Mediterrani included the complete Der Ring des Nibelungen cycle conducted by Zubin Mehta, again with Plácido Domingo.

The Queen Sofía company promotes symphonic concerts, opera galas, and vocal recitals. The company also hosts the Centre de Perfeccionament Plácido Domingo, an advanced training program of international draw for young opera artists, named in honor of Plácido Domingo. The program is run under the famous tenor's aegis.